Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored
Scott B. Halsteada✉, Nguyen Trong Lanb, Thein Thein Myintc, Than Nu Shwec, Ananda Nisalakd, Siripen Kalyanarooje, Suchitra Nimmannityae, Soegeng Soegijantof, David W. Vaughnd, Timothy P. Endyd
- aUniformed Services University of the Health Sciences, Bethesda, Maryland, USA
- bChildren’s Hospital No. 1, Ho Chi Minh City, Vietnam
- cYangon Children’s Hospital, Yangon, Myanmar
- dArmed Forces Research Institute of the Medical Sciences, Bangkok, Thailand
- eQueen Sirikit National Institute of Child Health, Bangkok, Thailand
- fDr. Soetomo Hospital, Airlangga University Medical School, Surabaya, Indonesia
- ✉Corresponding author
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Abstract
The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya, Indonesia. The four dengue viruses were isolated from Thai infants, all of whom were having a primary dengue infection. Progress studying the immunologically distinct infant DHF/DSS has been limited; most contemporary research has centered on DHF/DSS accompanying secondary dengue infections. In designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. Research challenges presented by infant DHF/DSS are discussed.
TL;DRIn designing research results obtained in studies on a congruent animal model, feline infectious peritonitis virus (FIPV) infections of kittens born to FIPV-immune queens should be considered. (Semantic Scholar)