SHORT REPORT: BENZNIDAZOLE EFFICACY AMONG TRYPANOSOMA CRUZI-INFECTED ADOLESCENTS AFTER A SIX-YEAR FOLLOW-UP
Ana Lúcia Sampaio Sgambatti de Andradea b c d, Celina Maria Turchi Martellia b c d, Renato Maurício de Oliveiraa b c d, Simonne A Silvaa b c d, ANDRÉA I. S. AIRESa b c d, Léa Mara Tosi Soussumia b c d, Dimas Tadeu Covasa b c d, Luiz S. Silvaa b c d, João Guimarães de Andradea b c d, Luiz Rodolpho Travassosa b c d, Igor Correia de Almeidaa b c d
- aInstitute of Tropical Pathology and Public Health, Department of Community Health, Federal University of Goias, Goiânia, Brazil
- bFundação Hemocentro de Ribeirão Preto, Ribeirão Preto, Sao Paulo, Brazil
- cDiscipline of Cell Biology, Federal University of Sao Paulo, Sao Paulo, Brazil
- dDepartment of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
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Abstract
Data from a six-year follow-up of Trypanosoma cruzi-infected adolescents enrolled in a randomized, double-blind, clinical trial of benznidazole showed successful chemotherapy in 64.7% (95% confidence interval [CI] = 50.2-78.7) and 84.7% (95% CI = 66.8-92.9), respectively, by intention-to treat and by per protocol analysis measured by seronegativity in a chemiluminescent enzyme-linked immunosorbent assay with a purified trypomastigote mucin antigen. No incident case of cardiomyopathy was detected by electrocardiogram assessment in this cohort of adolescents who had been infected in childhood. The persistent and consistently long-term negative serologic reactions suggest the absence of the parasite in the treated patients and reinforces the recommendation of early benznidazole chemotherapy for T. cruzi-infected infants as a public health policy in endemic areas.
TL;DRThe persistent and consistently long-term negative serologic reactions suggest the absence of the parasite in the treated patients and reinforces the recommendation of early benznidazole chemotherapy for T. cruzi-infected infants as a public health policy in endemic areas. (Semantic Scholar)