Comparative Susceptibility ofAedes albopictusandAedes aegyptito Dengue Virus Infection After Feeding on Blood of Viremic Humans: Implications for Public Health
James Whitehorna b c✉, Duong Thi Hue Kienc, Nguyet Minh Nguyenc, Hoa L. Nguyenc, Peter Kyrylosd, Lauren B. Carringtonc d e, Chau Nguyen Tranc, Nguyen Than Ha Quyenc, Long Thi Voc, Dui Le Thic, Nguyen Thanh Truongf,
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Abstract
Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. This study compared the susceptibility of these 2 species to DENV infection by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam. Field-derived A. albopictus acquired DENV infections as readily as A. aegypti after blood feeding. Once infected, A. albopictus permitted higher concentrations of DENV RNA to accumulate in abdominal tissues, compared with A. aegypti. However, the odds of A. albopictus having infectious saliva were lower than the odds observed for A. aegypti (odds ratio, 0.70; 95% confidence interval, .52-.93). These results quantitate the susceptibility of A. albopictus to DENV infection and will assist parameterization of models for predicting disease risk in settings where A. albopictus is present.
TL;DRThe susceptibility of A. albopictus to DENV infection is compared by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam to assist parameterization of models for predicting disease risk in settings where A. aegypti is present. (Semantic Scholar)