Genetic Properties of the Maize Nested Association Mapping Population
Michael D. McMullena b✉, Stephen Kresovichc✉, Héctor Sánchez‐Villedaa✉, Peter J. Bradburyb c, Huihui Lic d e, Qi Sunf, Sherry A. Flint-Garciaa b, Jeffry M. Thornsberryg, Charlotte B. Acharyac, Christopher A. Bottomsa, Patrick J. Brownc, Chris Browneb, Magen S. Ellerb, Kate E Guillb, Carlos Harjesc✉, Dallas E. Kroonc, Nick Lepakb, Sharon E. Mitchellc, Brooke Petersonb, Gaël Pressoirc✉, Susan M. Romerob, Marco A Oropeza-Rosash✉, Stella Salvob, Heather Yatesc, Mark Hansoni, Elizabeth Jonesj, Stephen J. Smithj, Jeffrey C. Glaubitzk, M. M. Goodmanh, Doreen Wareb l and 2 others
- aDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USA
- bUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)
- cInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USA
- dInstitute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China
- eSchool of Mathematical Science, Beijing Normal University, Beijing 100875, China
- fComputational Biology Service Unit, Cornell University, Ithaca, NY 14853, USA
- gNorthwest Missouri State University, Maryville, MO 64468, USA
- hDepartment of Crop Science, North Carolina State University, Raleigh, NC 27695, USA
- iIllumina Inc., San Diego, CA 92121, USA
- jPioneer Hi-Bred, Johnston, IA 50131, USA
- kLaboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
- l
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Abstract
Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.
TL;DRMaize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability and it is suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. (Semantic Scholar)