Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery
Goran T. Vladisavljevića, Nauman Khalidb c, Marcos A. Nevesb d, Takashi Kuroiwab e, Mitsutoshi Nakajimab d, Kunihiko Uemurab, Sosaku Ichikawad✉, Isao Kobayashib✉
- aChemical Engineering Department, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
- bFood Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan
- cGraduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
- dFaculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572, Japan
- eFaculty of Engineering, Tokyo City University, 1-28-1 Tamazutsumi, Setagaya-ku, Tokyo 158-8557, Japan
- ✉Corresponding author
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Abstract
Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.
TL;DRThis review describes the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition and describes some micro fluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. (Semantic Scholar)