Evolutionary History of Salmonella Typhi
Philippe Roumagnaca b c d e, François‐Xavier Weilla b c d e, Christiane Doleceka b c d e f, Stephen G. Bakera b c d e g, Sylvain Brissea b c d e, Nguyen Tran Chinha b c d e, Thi Anh Hong Lea b c d e, Camilo J. Acostaa b c d e✉, Jeremy Farrara b c d e f, Gordon Dougan Ba b c d e g, Mark Achtmana b c d e✉
- aHospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
- bInstitut Pasteur, Unité Biodiversité des Bactéries Pathogènes Emergentes, 28 rue du Docteur Roux, 75724 Paris cedex 15, France
- cMax-Planck-Institut für Infektionsbiologie, Department of Molecular Biology, Charitéplatz 1, 10117 Berlin, Germany
- dOxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
- eThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
- f3 Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam
- g4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
- ✉Corresponding author
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Abstract
For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.
TL;DRThe neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia, and antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. (Semantic Scholar)