Transmission of Human Immunodeficiency Virus Type 1 Resistant to Nevirapine and Zidovudine
Allison A. Imriea, Alexander Beveridgeb c d e f g, William Gennb c d e f g, Jeanette Vizzardd e f g h, David A. Cooperd e f g h, the Sydney Primary HIV Infection St Group
- aCentre for Immunology, St Vincent's Hospital, Grosvenor Clinic, Woolhara, Australia
- bCentre for Immunology , St Vincent's Hospital , Grosvenor Clinic , Woollhara , and
- cNational Centre in HIV Epidemiology and Clinical
- dCentre for Immunology, St Vincent's Hospital, Grosvenor Clinic, Woollhara, and National Centre in HIV Epidemiology and Clinical
- eEpidemiology and Clinical Research, University of New South Wales, 376
- fSydney Research, University of New South Wales, Sydney, Australia
- gSydney, NSW 2010, Australia
- hSydney Research , University of New South Wales , Sydney , Australia
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Abstract
Human immunodeficiency virus type 1 (HIV-1) resistant to the nonnucleoside reverse transcriptase inhibitor nevirapine and to the nucleoside analogue zidovudine was transmitted from a homosexual man to his sex partner. The virus source patient had commenced combination zidovudine and nevirapine therapy 2.5 years prior to his partner's primary HIV infection. He received both therapies for 7 months, then discontinued nevirapine treatment, continuing to receive zidovudine monotherapy for a further 16 months. He had ceased zidovudine therapy 6 months before the time of his partner's seroconversion. Analysis of major and minor isolates obtained from both patients soon after onset of the recipient's primary HIV infection illness confirmed that an HIV-1 variant mutant at codons 70, 98, and 181 of the viral reverse transcriptase was transmitted. This is the first documented case of transmission of HIV-1 resistant to two antiretroviral compounds.
TL;DRAnalysis of major and minor isolates obtained from both patients soon after onset of the recipient's primary HIV infection illness confirmed that an HIV-1 variant mutant at codons 70, 98, and 181 of the viral reverse transcriptase was transmitted. (Semantic Scholar)