Microbiologic Methods Utilized in the MAL-ED Cohort Study
Eric R. Houpta✉, Jean C. Gratza, Margaret N. Kosekb, Anita K. M. Zaidic, Shahida Qureshic, Gagandeep Kangd, Sudhir Babjid, Carl Jeffries Masone, Ladaporn Bodhidattae, Amidou Samief, Pascal Obong Bessongf, Leah J. Barretta, Aldo Â. M. Limag, Alexandre Havtg, Rashidul Haqueh, Dinesh Mondalh, Mami Taniuchia, Suzanne E. Stroupa, Monica McGrathi, Dennis Langi j, The MAL-ED Network Investigators
- aUniversity of Virginia, Charlottesville
- bJohns Hopkins University, Baltimore, Maryland
- cAga Khan University, Naushahro Feroze, Pakistan
- dChristian Medical College, Vellore, India
- eArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand
- fUniversity of Venda, Thohoyandou, South Africa
- gUniversidade Federal do Ceara, Fortaleza, Brazil
- hicddr,b, Dhaka, Bangladesh
- iFogarty International Center, National Institutes of Health
- jFoundation of the National Institutes of Health, Bethesda, Maryland
- ✉Corresponding author
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Abstract
A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals.
TL;DRThe rationale for the microbiologic assays chosen and methodologies used to accomplish the MAL-ED goals are described, including harmonized protocols to test for a diverse range of enteropathogens and maximum laboratory throughput and minimum cost. (Semantic Scholar)