Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam
Vũ Đình Thiểma, Jacqueline L. Deenb✉, Lorenz von Seidleinb, Do Gia Canha, Đặng Đức Anha, Jin-Kyung Parkb, Mohammad Alib, Maria Carolina Danovaro-Hollidayb, Nguyễn Đình Sơnc, Nguyen Thai Hoac, Jan R. Holmgrend, John David Clemensb e
- aNational Institute of Hygiene and Epidemiology, Hanoi, Vietnam
- bInternational Vaccine Institute, Seoul, Republic of Korea
- cThua Thien Hue Provincial Health Service, Hue, Vietnam
- dUniversity of Gothenburg, Sweden
- eNational Institute of Child Health and Human Development, Bethesda, MD, USA
- ✉Corresponding author
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Abstract
We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.
TL;DRThe overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). (Semantic Scholar)