Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005
S.A.M. Kularatnea b, Manoji Pathirageb c, P. V. R. Kumarasirid e, Sunethra Gunasenaf, S.I. Mahindawanseb c
- aDepartment of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. samkul@sltnet.lk <samkul@sltnet.lk>
- bDepartment of Medicine Faculty of Medicine University of Peradeniya Peradeniya Sri Lanka
- cDepartment of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
- dDepartment of Community Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
- eDept. of Community Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
- fMedical Research Institute, Colombo, Sri Lanka
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Abstract
A high incidence of cardiac complications was observed in an outbreak of dengue fever at General Hospital, Peradeniya, Sri Lanka, in 2005. This report describes 120 serologically confirmed dengue fever patients who presented during the outbreak. Seventy-five (62.5%) of these patients had electrocardiogram changes (T inversion, ST depression, bundle branch blocks) and were assigned to the 'cardiac group' (50 females, 25 males; median age 34 years, range 13-76). These patients were more susceptible to fatigue, dyspnoea, low peripheral oxygen saturation in room air (P=0.001), chest pain (P=0.001) and flushing of skin (P=0.05) than 45 (37.5%) patients who had normal electrocardiograms and made up the 'non-cardiac group'. In the cardiac group there were 31 primary and 44 secondary dengue patients. In the cardiac group, 17 (23%) patients had hypotension and 58 (77%) developed tachycardia and bradycardia (P<0.001) compared to four (9%) in the non-cardiac group, suggestive of significant cardiac dysfunction. There was no correlation between pulse rate and body temperature: cardiac group (r=0.05; P=0.63); non-cardiac group (r=0.11, P=0.46). RT-PCR detected DEN-3 in three cardiac patients.
TL;DRThis report describes 120 serologically confirmed dengue fever patients who presented during the outbreak and found that patients in the cardiac group were more susceptible to fatigue, dyspnoea, low peripheral oxygen saturation in room air, chest pain, and flushing of skin. (Semantic Scholar)