IL‐10 levels in Dengue patients: Some findings from the exceptional epidemiological conditions in Cuba
Ana B. Péreza b✉, Gissel Garcı́ab c, Beatríz Sierrab c, Mayling Álvarezb c, Susana Vázquezb c, María V. Cabrerad, Rosmary Rodríguezb c, Delfina Rosariob c, Eric Martíneze, Thomas N. Dennyf g h, María G. Guzmáni j
- aVirology Department, Pedro Kourí Tropical Medicine Institute, Ciudad de la Habana, Cuba. anab@ipk.sld.cu
- bVirology Department, “Pedro Kourí” Tropical Medicine Institute, Ciudad de la Habana, Cuba
- cVirology Department, “Pedro Kourí” Tropical Medicine Institute, Ciudad de la Habana, Cuba
- dProvincial Hospital of Santiago de Cuba, Santiago de Cuba, Cuba
- eMinisterio de Salud Publica, Ciudad de la Habana, Cuba
- fUMDNJ-New Jersey Medical School, Newark, New Jersey
- gUMDNJ-New Jersey Medical School
- hNewark New Jersey
- iWHO Collaborating Center for Viral Diseases, Virology Department, “Pedro Kourí” Tropical Medicine Institute, Ciudad de la Habana, Cuba
- jWHO Collaborating Center for Viral Diseases, Virology Department, “Pedro Kourí” Tropical Medicine Institute, Ciudad de la Habana, Cuba
- ✉Corresponding author
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Abstract
The pathogenesis associated with Dengue haemorrhagic fever, has yet to be fully elucidated, with no definitive in vivo evidence. The exceptional epidemiological circumstances in Cuba allow the evaluation of different mediators in a well-defined situation. In the present study, we describe the determination of levels of IL-12, IL-10 and RANTES in the sera of Cuban patients hospitalised with Dengue fever or Dengue haemorrhagic fever. The results showed that levels of serum IL-10 were higher in patients than controls, and those patients with secondary infections had consistently higher levels. All the Dengue haemorrhagic fever patients had increased levels of IL-10. In contrast, levels of IL-12 did not differ between patients and controls. Finally, RANTES serum levels detected in patients were lower than those observed in the controls. The association of increased levels of IL-10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease.
TL;DRThe association of increased levels of IL‐10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease. (Semantic Scholar)