Analysis of Repeat Hospital Admissions for Dengue to Estimate the Frequency of Third or Fourth Dengue Infections Resulting in Admissions and Dengue Hemorrhagic Fever, and Serotype Sequences
Robert V. Gibbonsa b c d e✉, Siripen Kalanarooja b c d e, Richard G. Jarmana b c d e, Ananda Nisalaka b c d e, David W. Vaughna b c d e, Timothy P. Endya b c d e, Mammen P. Mammena b c d e, Anon Srikiatkhachorna b c d e
- aQueen Sirikit Institute for Child Health, Bangkok, Thailand
- bDepartment of Virology, United States Army Medical Component–Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
- cCenter for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts
- dDivision of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland
- eMilitary Infectious Diseases Research Program
- ✉Corresponding author
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Abstract
Immunity to a single dengue virus (DENV) infection does not provide heterologous immunity to subsequent infection. In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with a second DENV serotype exposure. The risk for DHF with a third or fourth dengue infection relative to a first or second exposure is not known. An analysis of our database of children admitted to the Queen Sirikit National Institute of Child Health and Kamphaeng Phet Provincial Hospital with suspected dengue illness revealed that the number of dengue admissions caused by a third or fourth DENV infection was extremely low (0.08-0.8%). Once admitted, the risk for DHF relative to dengue fever was not different for those experiencing third or fourth DENV infections over those experiencing a second DENV infection. We document new dengue serotype infection sequences leading to DHF of 1-4, 2-3, 3-1, and 3-4.
TL;DRAn analysis of the database of children admitted to the Queen Sirikit National Institute of Child Health and Kamphaeng Phet Provincial Hospital with suspected dengue illness revealed that the number of d Dengue admissions caused by a third or fourth DENV infection was extremely low. (Semantic Scholar)