Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China
Zhilian Wanga, Zaibo Lib, Jing Lia, Chen Wanga c d, Wenhao Wanga, Min Haoa, Chengquan Zhaoa d
- aDepartment of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China
- bDepartment of Pathology, Ohio State Wexner Medical Center, Columbus, OH 43210, USA
- cDepartment of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, China
- dDepartment of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. 300 Halket St, Pittsburgh, PA, 15213, USA
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Abstract
Objective: The distribution of human papillomavirus (HPV) genotypes varies by countries and regions.Data regarding HPV genotype distribution for women with cervical intraepithelial neoplasia 2/3 (CIN2/3) are still limited.This study aimed to investigate the distribution of HPV genotypes for women with CIN2/3 in Shanxi province, China.Methods: Prior HPV testing/genotyping resulted from women with histologic diagnosis of CIN2/3 were retrospectively collected between August 2011 and August 2016.Results: A total of 1387 women with a diagnosis of CIN2/3 were included in this study.The average age of the women was 45.7 years and the average time period from HPV testing to histological diagnosis was 0.4 months.The overall high-risk HPV (hrHPV) positive rate was 91.6%.In all tested women, the most commonly detected hrHPV genotype was HPV16 (59.3%) followed by HPV58 (14.4%) and HPV33 (10.0%), while HPV18 was in the 6 th position (6.0%).Conclusions: This is one of the largest studies of HPV genotyping for women with CIN2/3 in China.The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries.Our results provide important information for developing specific HPV vaccines for Chinese women.
TL;DRThe prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries, providing important information for developing specific HPV vaccines for Chinese women. (Semantic Scholar)