Stroke Prognosis: The Impact of Combined Thrombotic, Lipid, and Inflammatory Markers
Lamia Mbareka b, Aoming Jina b, Yuesong Pana b, Jinxi Lina b, Yong Jianga, Xia Menga, Yongjun Wanga b c d e f
- aChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University
- bDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University
- cAdvanced Innovation Center for Human Brain Protection, Capital Medical University
- dCenter for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
- eResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences
- fResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, 2019RU018
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Abstract
AIM: D-dimer, lipoprotein (a) (Lp(a)), and high-sensitivity C-reactive protein (hs-CRP) are known predictors of vascular events; however, their impact on the stroke prognosis is unclear. This study used data from the Third China National Stroke Registry (CNSR-III) to assess their combined effect on functional disability and mortality after acute ischemic stroke (AIS). METHODS: In total, 9,450 adult patients with AIS were enrolled between August 2015 and March 2018. Patients were categorized based on a cutoff value for D-dimer, Lp(a), and hs-CRP in the plasma. Adverse outcomes included poor functional outcomes (modified Rankin Scale (mRS score ≥ 3)) and one- year all-cause mortality. Logistic and multivariate Cox regression analyses were performed to investigate the relationship between individual and combined biomarkers and adverse outcomes. RESULTS: Patients with elevated levels of all three biomarkers had the highest odds of functional disability (OR adjusted: 2.01; 95% CI (1.47-2.74); P＜0.001) and mortality (HR adjusted: 2.93; 95% CI (1.55-5.33); P＜0.001). The combined biomarkers improved the predictive accuracy for disability (C-statistic 0.80 vs.0.79, P＜0.001) and mortality (C-statistic 0.79 vs.0.78, P=0.01). CONCLUSION: Elevated D-dimer, Lp(a), and hs-CRP levels together increase the risk of functional disability and mortality one-year post-AIS more than any single biomarker.
TL;DRElevated D-dimer, Lp(a), and hs-CRP levels together increase the risk of functional disability and mortality one-year post-AIS more than any single biomarker. (Semantic Scholar)