Synthesis and Investigation of Antibacterial Activity of Thin Films Based on TiO2-Ag and SiO2-Ag with Potential Applications in Medical Environment
Cristina Adochițea, Cătălin Vițelarub✉, Anca Constantina Pârăub, Adrian Emil Kissb, Iulian Panăb, Alina Vlădescub c, Sarah Costinașa, Marius Mogaa, Radu Munteand, Mihaela Badeaa✉, Mihaela Elena Idomira
- aFaculty of Medicine, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania
- bNational Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania
- cPhysical Materials Science and Composite Materials Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Lenin Avenue 43, 634050 Tomsk, Russia
- dFaculty of Civil Engineering, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania
- ✉Corresponding author
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Abstract
Multiple antibiotic resistance has now become a major obstacle to the treatment of infectious diseases. In this context, the application of nanotechnology in medicine is a promising alternative for the prevention of infections with multidrug-resistant germs. The use of silver as a powerful antibacterial agent has attracted much interest. TiO2 and SiO2 thin films enhanced with Ag particles have been developed with the aim of maintaining the transparency of the polymer films. Antibacterial activity was evaluated for a Gram-negative species-Escherichia coli-in concentrations of 105 and 104 CFU/mL in different conditions-activation by UV irradiation, single layer and double layer. Increased antibacterial efficacy of TiO2-deposited foil was found for the tests that had been exposed to UV activation. In the case of bilayer tests, the efficiency was higher compared to those in a single layer, as the contact surface between the films and the bacterial suspension increased. Films can be used as a potential method to limit bacterial growth on hospital surfaces, such as telephone screens and medical equipment, given their optimized characteristics and proven antibacterial efficacy.
TL;DRTiO2 and SiO2 thin films enhanced with Ag particles have been developed with the aim of maintaining the transparency of the polymer films, and increased antibacterial efficacy of TiO2-deposited foil was found for the tests that had been exposed to UV activation. (Semantic Scholar)