article Open access
Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024
Phoebe Stevenson-Leggett, Lorin Adams, David Greenwood, Abi Lofts, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Charles Swanton, Steve J. Gamblin, Edward J Carr, Ruth Harvey, Nicola S. Lewis, Mary Wu, Emma CB Wall, Legacy Investigators
Emerging infectious diseasesCenters for Disease Control and Prevention2025-05-28 6 citations14 references
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Abstract
We tested cross-neutralization against highly pathogenic avian influenza A(H5N1) virus in adults vaccinated with 2021-2023 seasonal quadrivalent influenza vaccine in the United Kingdom. Seasonal quadrivalent influenza vaccines are unlikely to protect vulnerable persons against severe H5N1 disease during widespread transmission. Enhanced measures are needed to protect vulnerable people from H5N1 virus infection.