FORMULATION, CHARACTERIZATION, AND OPTIMIZATION OF NANOPARTICLE-BASED GELS FOR TOPICAL DRUG DELIVERY

This study focuses on the development, evaluation, and optimization of nanoparticle-based gel formulations (NG1-NG10) for enhanced topical drug delivery, specifically targeting anti-inflammatory and wound-healing applications.Various formulations were prepared using a nanoparticulate system, and their physicochemical properties, including viscosity, spreadability, pH, and homogeneity, were assessed to determine their suitability for topical use.The formulations were tested for drug release, stability under different environmental conditions, and extrudability.Among the ten formulations, NG5 and NG2 consistently demonstrated superior performance in terms of physical characteristics, drug release, and stability.NG5, in particular, exhibited optimal viscosity (120,000 cps) and spreadability (6.1 cm²), making it ideal for effective topical application.Formulations NG1 to NG8 displayed suitable pH values, ensuring good skin compatibility.The stability studies showed that NG5 and NG7 were the most stable formulations, with minimal degradation over time.These findings suggest that nanoparticle-based gels, particularly NG5 and NG2, offer a promising strategy for topical drug delivery, combining high therapeutic efficacy, stability, and ease of use.Further studies will focus on the clinical application and refinement of these formulations for improved therapeutic outcomes.