The Role of Resveratrol in Alzheimer's Disease: A Comprehensive Review of Current Research
Shivendra Kumara b✉, Sunam Sahaa b, Bhawna Sharmac d, Shubham Singhc d, Piyush Shuklae f, Soumyadip Mukherjeea b, Mohit Agarwalg h i, Kuldeep Singha b, Talever Singha b
- aDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
- bRajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
- cDepartment of Pharmaceutics, Madhyanchal Professional University (Patel College of Pharmacy), Bhopal (M.P.), India
- dMadhyanchal Professional University, Bhopal (M.P.), India
- eDepartment of Pharmacology, Kunwar Ajeet College of Pharmacy, Jaunpur, Uttar Pradesh, India
- fKunwar Ajeet College of Pharmacy, Jaunpur, Uttar Pradesh, India
- gDepartment of Pharmacy, School of Medical &
- hAllied Sciences, G.D. Goenka University, Gurugram, Haryana, India
- iSchool of Medical &
- ✉Corresponding author
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Abstract
: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progres-sive cognitive decline, memory loss, and impaired daily functioning. The etiology of AD is complex and multifactorial, involving various pathological mechanisms such as the accumula-tion of amyloid-beta plaques, neurofibrillary tangles, neuroinflammation, and oxidative stress. As the global prevalence of AD continues to rise, there is a growing interest in identifying po-tential therapeutic interventions to prevent or slow down the progression of the disease. Resvera-trol, a natural polyphenolic compound found in various plant sources such as grapes, berries, and peanuts, has gained considerable attention due to its potential neuroprotective effects. Numerous preclinical studies utilizing in vitro and animal models have investigated the impact of resvera-trol on AD pathology and associated cognitive impairments. This review aims to provide a com-prehensive summary of the current research on the role of resveratrol in AD. In conclusion, resveratrol holds promise as a potential therapeutic agent for AD due to its ability to target mul-tiple pathological processes involved in the disease. Further research, including well-designed clinical trials with larger sample sizes, is needed to fully elucidate the efficacy, optimal dosage, and long-term effects of resveratrol in AD patients. Nevertheless, resveratrol remains an intri-guing compound with neuroprotective properties and may contribute to the development of nov-el therapeutic approaches for AD in the future.