Pharmacological Approaches and Herbal Interventions for Alzheimer's Disease
Shivendra Kumara✉, Shubham Singhb, Dharmendra Rajputb, Bhawna Sharmab, Kumkum Chaturvedic, Nidhi Singhd, Sunam Sahaa, Kuldeep Singha, Soumyadip Mukherjeea
- aRajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
- bMadhyanchal Professional University, (Patel College of Pharmacy), Bhopal, Madhya Pradesh, India
- cLNCT University, Kolar Road, Bhopal (M.P.), India
- dBBD NIIT, Lucknow (U.P.), India
- ✉Corresponding author
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Abstract
Abstract: This comprehensive review extensively examines the utilization of herbal remedies and pharmacological techniques for managing Alzheimer's disease (AD). It delves deeply into the active constituents and modes of operation of diverse herbal medications such as Withania somnifera, Bacopa monnieri, Ginkgo biloba, and Curcuma longa, emphasizing their qualities in reducing inflammation, acting as antioxidants, and safeguarding neural tissue. Additionally, it assesses conventional pharmaceuticals like cholinesterase inhibitors (Donepezil, rivastigmine) and memantine, investigating their mechanisms of action and potential adverse effects. The study also encompasses non-pharmacological therapies like interventions aimed at cognition, physical exercise, and methods of stimulating the brain, all of which exhibit potential in enhancing cognitive capacity and neural adaptability. Furthermore, it delves into the amalgamation of therapies to tackle numerous facets of AD pathology. In essence, this review furnishes valuable insights into alternative strategies for managing AD, underscoring the potential of herbal interventions in enhancing cognitive function and addressing the underlying issues of AD. Additionally, it presents a fresh avenue for exploring the collaborative impacts of combining conventional pharmaceuticals with herbal remedies.
TL;DRThis comprehensive review extensively examines the utilization of herbal remedies and pharmacological techniques for managing Alzheimer's disease, underscoring the potential of herbal interventions in enhancing cognitive function and addressing the underlying issues of AD. (Semantic Scholar)