Recent Advances in Enzyme Inhibition: A Pharmacological Review
Kuldeep Singha✉, Bharat Bhushanb, Nidhi Mittalc, Abhishek Kushwahad, Chandan Kumar Raikware, Arun Kumar Sharmaf, Dilip Kumar Chanchalg, Shivendra Kumara, Mohit Agrawalh i
- aDepartment of Pharmacology, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
- bDepartment of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
- cDepartment of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India
- dDepartment of Pharmacology, Arya College of Pharmacy Kukas, Jaipur, Rajasthan, India
- eDepartment of Pharmaceutics, Sanskriti College of Higher Education and Studies, Bhognipur, Kanpur Dehat, Uttar Pradesh, India
- fDepartment of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India
- gDepartment of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India
- hDepartment of Pharmacy, School of Medical &
- iAllied Sciences, G.D. Goenka University, Gurugram, Haryana, India
- ✉Corresponding author
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Abstract
Abstract: Enzyme inhibition is a crucial mechanism for regulating biological processes and developing therapeutic interventions. This pharmacological review summarizes recent advances in enzyme inhibition, focusing on key developments and their implications for drug discovery and therapeutic strategies. It explains basic ideas, including the different kinds of inhibitors and how they work, and looks at recent advances in small-molecule inhibitor design, fragment-based drug discovery, and virtual screening techniques. The review also highlights the advances in targeting specific enzyme families, explaining the structural basis of enzyme-inhibitor interactions, optimizing inhibitor potency, selectivity, and pharmacokinetic properties, and new trends in enzyme inhibition. The clinical implications of recent advances in enzyme inhibition include the development of novel therapeutic agents for diseases like cancer, infectious diseases, and neurological disorders. The review addresses challenges and future directions in the field, such as optimizing drug safety, resistance mechanisms, and personalized medicine approaches. Overall, the insights provided in this review may inspire further research and collaborations to accelerate the translation of enzyme inhibitors into effective clinical treatments.
TL;DRThis pharmacological review summarizes recent advances in enzyme inhibition, focusing on key developments and their implications for drug discovery and therapeutic strategies, and explains basic ideas, including the different kinds of inhibitors and how they work. (Semantic Scholar)