Advancement in schiff base complexes for treatment of colon cancer
Afaf Murtadha Kadhuma, S. H. Mallaha, A. S. Waheeba b, Abbas Washeel Salmanc, A. Zafard, Nafees Ahmadd, Saira Sirajd, M. Iqbald
- aDepartment of Chemistry , College of Science, Al-Muthanna , Al-Samawah , Iraq
- bInorganic Chemistry Group , Scientific Research Center, Al-Ayen University , Thi-Qar , Iraq
- cDepartment of Production , College of Agriculture, Wasit University , Kut , Iraq
- dDepartment of Chemistry , 66724 University of Agriculture Faisalabad , Faisalabad , 38040 , Pakistan
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Abstract
Abstract Schiff bases have proven to be beneficial in medicine and have interesting complexation capabilities with transition metals. The +4, +5, and +6 oxidation states of schiff base metal complexes have been the subject of recent review, which have highlighted their notable cytotoxic effects against various colon cancer cell lines (HT-29, HCT-116, SW-480, Coco-2, CT-26, LT-174, LoVo). Extensive research has focused on schiff base metal complexes in the +4 and +6 oxidation states, exhibiting distinct geometries and significant thermodynamic stability. These studies provide IC50 values for these complexes in colon cancer cell lines along with comprehensive structural representations that shed light on how different substituents affect cytotoxicity. When compared to schiff base ligands alone, metal complexes of schiff bases have been shown to significantly reduce colon cancer cell invasion and proliferation. The studied literature emphasizes schiff base metal complexe’s potential in biological applications and suggests that more study may be necessary to fully comprehend their biology. To enable more sophisticated multidisciplinary study in this field, future investigations should focus on synthesizing novel complexes with enhanced bioavailability, solubility, and low toxicity.
TL;DRThese studies provide IC50 values for schiff base metal complexes in colon cancer cell lines along with comprehensive structural representations that shed light on how different substituents affect cytotoxicity. (Semantic Scholar)