A Comparison of Triple and Quadruple Therapy Eradication Rates of H. pylori in a Community-Based Practice

Introduction:Helicobacter pylori (H. pylori) treatment eradication rates have been steadily decreasing. The most recent studies in the U.S. report eradication rates in the 70-80% range with triple or quadruple therapy for a treatment duration often to fourteen days. This study investigates the eradication rates in a community practice, comparing the two standard of care therapies. The primary purpose of this study is to analyze the eradication rates of these two therapies and identify an optimal first line treatment in our community. Methods: Retrospective chart review of all H. pylori positive test results between 2013-2015. Positive tests were defined as stool antigen positive, biopsy confirmed, or urea breath test positive. Eradication was determined by post-therapy urea breath testing Results: There were 78 patients in the treatment group; 38 in BMTP and 40 in LAC. In the BMT treatment arm, there were 47% men and 53% women. The LAC treatment group had 65% men and 35% women. Confirmed eradication rates for BMTP and LAC were 89.5% and 77.5%, respectively. Conclusion: Preliminary results suggest that the eradication rates of BMTP and LAC are significantly different. Further analysis is currently under way to test this hypothesis. The results of this study in our community can potentially suggest an optimal first line therapy.