Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts’ meeting on serum biomarkers
Kirsten E. Wiensa, Bárbara Jaúreguib, Benjamin F. Arnoldc d, Kathryn K. Bankee, Djibril Wadef, Kyla T. Hayfordg, Adriana Costero‐Saint Denish, ROBERT H. HALLh, Henrik Saljei, Isabel Rodríguez-Barraquerj k, Andrew S. Azmana l m, Guy Vernetb n, Daniel T. Leungo p✉
- aDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- bMérieux Foundation USA, Washington, District of Columbia, United States of America
- cDepartment of Ophthalmology, University of California, San Francisco, California, United States of America
- dFrancis I. Proctor Foundation, University of California, San Francisco, California, United States of America
- eBill & Melinda Gates Foundation, Seattle, Washington, United States of America
- fInstitut de Recherche en Santé, de Surveillance Epidémiologique et de Formation (IRESSEF), Dakar, Senegal
- gInternational vaccine access center (IVAC), Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
- hDivision of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Maryland, United States of America
- iDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom
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Abstract
The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational modeling are transforming serosurveillance into a powerful tool for public health program design and response to infectious threats. In July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. Here, we summarize the group's insights and proposed roadmap for implementation, including objectives, technical requirements, ethical issues, logistical considerations, and monitoring and evaluation.
TL;DRIn July 2018, 70 scientists from 16 countries met to perform a landscape analysis of approaches that support an integrated serosurveillance platform, including the consideration of issues for successful implementation. (Semantic Scholar)