Additional chromosomal abnormalities in Philadelphia positive chronic myeloid leukemia
Sunila Tashfeen Arifa, Rafia Mahmoodb c, Saleem Ahmed Khand e f, Tahir Khadimc g h
- aCMH Quetta
- bDr. Rafia Mahmood, FCPS. Armed Forces Institute of Pathology, Rawalpindi, Pakistan
- cD Haematology, Army Medical College, Rawalpindi, Pakistan
- dDr. Saleem Ahmed Khan, FCPS, Ph D Haematology, Army Medical College, Rawalpindi, Pakistan
- eDepartment of Pathology, Combined Military Hospital, Quetta, Pakistan
- fFCPS. H.No.10, Chiltan Road, Quetta Cantt, Quetta, Pakistan
- gDr. Tahir Khadim, FCPS. Armed Forces Institute of Pathology, Rawalpindi, Pakistan
- h: Armed Forces Institute of Pathology, Rawalpindi, Pakistan
Papers open inside SciRah from the original publisher or repository; SciRah never hosts them.
Abstract
Objective: To determine the frequency of additional chromosomal abnormalities in Philadelphia chromosome positive Chronic Myeloid Leukemia (CML) by conventional cytogenetic analysis. Methods: This descriptive cross sectional study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January 2012 to December 2016. A total number of 528 newly diagnosed CML patients were included in the study. The subjects were tested for the presence of Philadelphia (Ph) chromosome and other additional cytogenetic abnormalities by conventional cytogenetic analysis interpreted according to International System of Human Cytogenetic Nomenclature (ISCN) criteria. Molecular analysis for BCR-ABL was also performed for each patient. The additional cytogenetic abnormalities were then classified into major route abnormalities and minor route abnormalities. Results: Out of the 528 newly diagnosed CML patients, 378 (71.6%) were males and 150 (28.4%) were females. The age of patients ranged between 18 to 74 years. Four hundred and ninety-eight (94.3%) patients showed Philadelphia chromosome on karyotyping while 30 (5.7%) were negative for the Philadelphia chromosome. On analysis of these 498 Philadelphia positive patients, additional cytogenetic aberrations were detected in 26 (4.9%) patients. Of these, 7 (1.3%) had major route abnormalities while 19 (3.6%) had minor route abnormalities. Conclusion: The frequency of additional chromosomal abnormalities in our study were not in accordance with previous local and international studies. doi: https://doi.org/10.12669/pjms.36.2.1384 How to cite this:Tashfeen S, Mahmood R, Khan SA, Khadim T. Additional chromosomal abnormalities in Philadelphia positive chronic myeloid leukemia. Pak J Med Sci. 2020;36(2):208-212. doi: https://doi.org/10.12669/pjms.36.2.1384 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
TL;DRThe frequency of additional chromosomal abnormalities in Philadelphia chromosome positive Chronic Myeloid Leukemia patients tested by conventional cytogenetic analysis were not in accordance with previous local and international studies. (Semantic Scholar)