Yi Donga b, Kun Fanga c, Xin Wangd e, Jianhua Zhuangf g, Xueyuan Liuh i, Taiyang Guanj k, Xiaofei Yul m, Gang Lin o, Jian‐Ren Liup q, Yi Fur s, Qiang Dong
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Objective: The underlying mechanisms of high recurrence of ischemic stroke in Chinese population are unclear. Our study is to determine sex differences in recurrent stroke and hospital mortality after a recurrent stroke in Chinese population. Methods: Shanghai Stroke Service System is a quality improvement project based on the EHR system. All stroke population who were hospitalized in 2018 for acute ischemic stroke within 7 days were prospectively extracted. The ORs for recurrent ischemic stroke were calculated with adjustment for demographics and risk factors. Results: Among 21,805 acute ischemic stroke patients in Shanghai Stroke Service System, having an ischemic stroke (mean age 69 years [SD 12 years], 63.7% male). About 21.8% of patients had a recurrent stroke (95%CI 21.3-22.4%). The multivariable logistic regression suggested that recurrent stroke population have more vascular risk factors, compared to first-ever stroke population. Furthermore, the sex differences in risk factors were gradually increasing, but reduction in smoking (35% vs. 28% in male; 2% vs 1.8% in female) and alcoholic status (22% vs. 18% in male; 1.9% vs 1.4% in female). The ORs of recurrent rate in male stroke population compared with in female was 0.74 (95% CI 0.62-0.79) after multivariable adjusted. The hospital mortality after recurrent stroke for male and female was 2.1% (95% CI 1.6%-2.6%) and 3.1% (95% CI 2.3%-4.1%), respectively. The multivariable-adjusted relative risk for hospitalization mortality of a recurrent stroke was 1.19 (95% CI 0.94-1.50). There is no significant difference impact on mortality between sex (aOR 1.08, 95% 0.72-1.63). Conclusion: The vascular risk factors in recurrent stroke population were mostly increasing, compared to those with first-ever stroke. However, the rates of smoking and alcoholism were reduced in male but not in female. The hospitalization mortality rate in recurrent stroke was similar to those with first-ever stroke population.
TL;DRThe aim of this study is to determine sex differences in recurrent stroke and hospital mortality in Chinese population and to investigate the underlying mechanisms of high recurrence of ischemic stroke. (Semantic Scholar)
