HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis
Leiyun Yanga b, Xiangsong Chenc d e f, Zhixue Wanga b, Qi Sung h, Anna Honga b, Aiqin Zhanga b, Xuehua Zhongc d e f✉, Jian Huaa b✉
- aPlant Biology Section School of Integrative Plant Science Cornell University Ithaca NY 14853 USA
- bPlant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853 USA
- cLaboratory of Genetics University of Wisconsin‐Madison Madison WI 53706 USA
- dWisconsin Institute for Discovery University of Wisconsin‐Madison Madison WI 53706 USA
- eLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, 53706 USA
- fWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53706 USA
- gCornell Computational Biology Service Unit Cornell University Ithaca NY 14853 USA
- hCornell Computational Biology Service Unit, Cornell University, Ithaca, NY, 14853 USA
- ✉Corresponding author
Papers open inside SciRah from the original publisher or repository; SciRah never hosts them.
Abstract
Plant immune responses need to be tightly controlled for growth-defense balance. The mechanism underlying this tight control is not fully understood. Here we identify epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) genes as an important mechanism for immune responses. Through a sensitized genetic screen and molecular studies, we identified and characterized HOS15 and its associated protein HDA9 as negative regulators of immunity and NLR gene expression. The loss-of-function of HOS15 or HDA9 confers enhanced resistance to pathogen infection accompanied with increased expression of one-third of the 207 NLR genes in Arabidopsis thaliana. HOS15 and HDA9 are physically associated with some of these NLR genes and repress their expression likely through reducing the acetylation of H3K9 at these loci. In addition, these NLR genes are repressed by HOS15 under both pathogenic and nonpathogenic conditions but by HDA9 only under infection condition. Together, this study uncovers a previously uncharacterized histone deacetylase complex in plant immunity and highlights the importance of epigenetic regulation of NLR genes in modulating growth-defense balance.
TL;DRA previously uncharacterized histone deacetylase complex in plant immunity is uncovers and the importance of epigenetic regulation of NLR genes in modulating growth-defense balance is highlighted. (Semantic Scholar)