Structural brain correlates of adolescent resilience · SciRah

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Structural brain correlates of adolescent resilience

Keith B. Burt^{a b}✉, Robert Whelan^{c d}, Patricia Conrod^{e f g}, Tobias Banaschewski^{h i}, Gareth J. Barker^{f g}, Arun L.W. Bokde^{j k}, Uli Bromberg^{l m}, Christian Büchel^{l m}, Mira Fauth‐Bühler^{n o}, Herta Flor^{h i}, André Galinowski^{p q r},

Journal of Child Psychology and Psychiatry Wiley2016-04-15 83 citations50 references

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Abstract

BACKGROUND: Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. METHODS: = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. RESULTS: The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. CONCLUSIONS: We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.

TL;DRThe interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. (Semantic Scholar)

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Discussion

^aDepartment of Psychology University of Vermont Burlington VT USA
^bDepartment of Psychology, University of Vermont, Burlington, VT, USA
^cDepartment of Psychology University College Dublin Dublin Ireland
^dDepartment of Psychology, University College Dublin, Dublin, Ireland
^eDepartment of Psychiatry CHU Ste Justine Hospital Université de Montréal Montreal QC Canada
^fInstitute of Psychiatry King's College London London UK
^gInstitute of Psychiatry, King's College London, London, UK
^hDepartment of Cognitive and Clinical Neuroscience Medical Faculty Mannheim Heidelberg University Mannheim Germany
ⁱDepartment of Cognitive and Clinical Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
^jInstitute of Neuroscience and Discipline of Psychiatry School of Medicine Trinity College Dublin Dublin Ireland
^kInstitute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland
^lUniversitaetsklinikum Hamburg Eppendorf Hamburg Germany
^mUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany
ⁿDepartment of Addictive Behaviour and Addiction Medicine Central Institute of Mental Health Medical Faculty Mannheim Heidelberg University Mannheim Germany
^oDepartment of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
^pAP‐HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn University Paris Descartes Paris France
^qInstitut National de la Santé et de la Recherche Médicale INSERM CEA Unit 1000 ‘Imaging &amp
^rPsychiatry’ University Paris Sud Orsay France
^sDepartment of Psychiatry and Psychotherapy Campus Charité Mitte Charité – Universitätsmedizin Berlin Berlin Germany
^tSchool of Physics and Astronomy University of Nottingham Nottingham UK
^uSchool of Physics and Astronomy, University of Nottingham, Nottingham, UK
^vPhysikalisch‐Technische Bundesanstalt (PTB) Braunschweig Germany
^wPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany
^xNeurospin Commissariat à l'Energie Atomique et aux Energies Alternatives Paris France
^yMontreal Neurological Institute McGill University Montréal QC Canada
^zRotman Research Institute University of Toronto Toronto ON Canada
^aaSchool of Psychology University of Nottingham Nottingham UK
^abRotman Research Institute, University of Toronto, Toronto, ON, Canada
^acSchool of Psychology, University of Nottingham, Nottingham, UK
^adThe Hospital for Sick Children University of Toronto Toronto ON Canada
^aeThe Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
^afDepartment of Child and Adolescent Psychiatry and Psychiatry Central Institute of Mental Health Medical Faculty Mannheim Heidelberg University Mannheim Germany
^agDepartment of Child and Adolescent Psychiatry and Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
^ahDepartment of Experimental Psychology Behavioural and Clinical Neurosciences Institute University of Cambridge Cambridge UK
^aiDepartment of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
^ajDepartment of Psychiatry and Neuroimaging Center Technische Universität Dresden Dresden Germany
^akMRC Social Genetic and Developmental Psychiatry (SGDP) Centre London UK
^alMRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK
^amDepartment of Psychiatry University of Vermont Burlington VT USA
^anDepartment of Psychiatry, University of Vermont, Burlington, VT, USA
✉Corresponding author