The biology of hematopoietic stem cells and its clinical implications
Izabella Skulimowskaa b, Justyna Sośniaka b, Monika Gońkaa b, Agata Szadea b, Alicja Józkowicza b, Krzysztof Szadea b✉
- aDepartment of Medical Biotechnology Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University Krakow Poland
- bDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
- ✉Corresponding author
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Abstract
Hematopoietic stem cells (HSCs) give rise to all types of blood cells and self-renew their own population. The regeneration potential of HSCs has already been successfully translated into clinical applications. However, recent studies on the biology of HSCs may further extend their clinical use in future. The roles of HSCs in native hematopoiesis and in transplantation settings may differ. Furthermore, the heterogenic pool of HSCs dynamically changes during aging. These changes also involve the complex interactions of HSCs with the bone marrow niche. Here, we review the opportunities and challenges of these findings to improve the clinical use of HSCs. We describe new methods of HSCs mobilization and conditioning for the transplantation of HSCs. Finally, we highlight the research findings that may lead to overcoming the current limitations of HSC transplantation and broaden the patient group that can benefit from the clinical potential of HSCs.
TL;DRThe opportunities and challenges of recent studies on the biology of HSCs are reviewed and new methods of Hscs mobilization and conditioning for the transplantation of H SCs are described. (Semantic Scholar)