Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?
Pedro Escolla b, Carmen Buchriesera b✉
- aInstitut Pasteur Biologie des Bactéries Intracellulaires Paris France
- bUMR 3525 CNRS Paris France
- ✉Corresponding author
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Abstract
The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells. In this Review, we will summarize current knowledge on metabolic reprogramming and discuss putative causes underlying the preferential remodelling of host cells to Warburg-like metabolic programs during infection by intracellular bacteria.
TL;DRCurrent knowledge on metabolic reprogramming is summarized and putative causes underlying the preferential remodelling of host cells to Warburg‐like metabolic programs during infection by intracellular bacteria are discussed. (Semantic Scholar)