Transcribing RNA polymerase III observed by electron cryomicroscopy
Niklas A. Hoffmanna b, Arjen J. Jakobia b, Matthias K. Vorländera b, Carsten Sachsea b, Christoph W. Müllera b✉
- aEuropean Molecular Biology Laboratory (EMBL) Structural and Computational Biology Unit Heidelberg Germany
- bEuropean Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany
- ✉Corresponding author
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Abstract
Electron cryomicroscopy reconstructions of elongating RNA polymerase (Pol) III at 3.9 Å resolution and of unbound Pol III (apo Pol III) in two distinct conformations at 4.6 Å and 4.7 Å resolution allow the construction of complete atomic models of Pol III and provide new functional insights into the adaption of Pol III to fulfill its specific transcription tasks.
TL;DRElectron cryomicroscopy reconstructions of elongating RNA polymerase (Pol) III at 3.9 Å resolution and of unbound Pol III (apo Pol III) in two distinct conformations at 4.7 Åresolution allow the construction of complete atomic models of Pol III and provide new functional insights into the adaption of PolIII to fulfill its specific transcription tasks. (Semantic Scholar)