Dengue virus (DENV)-specific antibodies enhance Brazilian Zika virus (ZIKV) infection
Priscila M. S. Castanhaa b c d, Eduardo J. M. Nascimentoe f g h, Braga Cynthiac i, Marli Tenório Cordeiroa c, Otávio Valério de Carvalhoa c j, Leila Rodrigues de Mendonçaa c, Elisa de Almeida Neves Azevedoa c, Rafael Freitas de Oliveira Françaa c, Rafael Dháliac, Ernesto T. A. Marquesa c e f g h
- aAggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil
- bFaculty of Medical Science/ Institute of Biological Science, University of Pernambuco, Recife, Brazil
- cAggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife
- dFaculty of Medical Science/ Institute of Biological Science, University of Pernambuco, Recife
- eCenter for Vaccine Research, University of Pittsburgh, Pennsylvania, USA
- fDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania, USA
- gCenter for Vaccine Research and
- hDepartment of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania
- iInstituto de Medicina Integral Prof. Fernando Figueira, Recife, and
- jUniversidade Federal de Viçosa, Minas Gerais, Brazil
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Abstract
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
TL;DRIt is demonstrated that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line and that serum samples from d Dengue-immune pregnant women enhanced ZikV infection. (Semantic Scholar)