Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures
Tsukasa Tominaria b, Chiho Matsumotoa, Kenta Watanabea, Michiko Hirataa, Florian M. W. Grundlerb c, Masaki Inadaa b, Chisato Miyauraa b✉
- aDepartment of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
- bInstitute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo, Japan
- cInstitute of Crop Science and Resource Conservation, University of Bonn, Bonn, Germany
- ✉Corresponding author
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Abstract
Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health.
TL;DRLutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption and the survival of mature osteoclasts was suppressed by lutein in cultures. (Semantic Scholar)