Nickel–Platinum Nanoparticles as Peroxidase Mimics with a Record High Catalytic Efficiency
Zheng Xia, Kecheng Weib, Qingxiao Wangc, Moon Jae Kimc, Shouheng Sunb, Victor Fungd✉, Xiaohu Xiae✉
- aDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States
- bDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, United States
- cDepartment of Materials Science and Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States
- dCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States
- eDepartment of Chemistry and Nanoscience Technology Center, University of Central Florida, Orlando, Florida 32816, United States
- ✉Corresponding author
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Abstract
While nanoscale mimics of peroxidase have been extensively developed over the past decade or so, their catalytic efficiency as a key parameter has not been substantially improved in recent years. Herein, we report a class of highly efficient peroxidase mimic–nickel–platinum nanoparticles (Ni–Pt NPs) that consist of nickel-rich cores and platinum-rich shells. The Ni–Pt NPs exhibit a record high catalytic efficiency with a catalytic constant ( K cat ) as high as 4.5 × 10 7 s –1, which is ∼46- and 10 4 -fold greater than the K cat values of conventional Pt nanoparticles and natural peroxidases, respectively. Density functional theory calculations reveal that the unique surface structure of Ni–Pt NPs weakens the adsorption of key intermediates during catalysis, which boosts the catalytic efficiency. The Ni–Pt NPs were applied to an immunoassay of a carcinoembryonic antigen that achieved an ultralow detection limit of 1.1 pg/mL, hundreds of times lower than that of the conventional enzyme-based assay.
TL;DRDensity functional theory calculations reveal that the unique surface structure of Ni-Pt NPs weakens the adsorption of key intermediates during catalysis, which boosts the catalytic efficiency. (Semantic Scholar)