Plasmonic Metasurfaces Based on Pyramidal Nanoholes for High-Efficiency SERS Biosensing
Giovanna Palermoa b, Massimo Rippac d, Ylli Contib, Ambra Vestric d, Riccardo Castagnac d, Giovanna Fuscoe, Elisabetta Suffredinie, Jun Zhouf g, Joseph Zyssh, Antonio De Lucaa b✉, Lucia Pettic d✉
- aCNR NANOTEC—Istituto di Nanotecnologia, UOS Cosenza, 87036 Rende, CS, Italy
- bDepartment of Physics, University of Calabria, Via P. Bucci, 87036 Rende, CS, Italy
- cInstitute of Applied Sciences and Intelligent Systems ”E. Caianiello” CNR, 80078 Pozzuoli, Italy
- dInstitute of Applied Sciences and Intelligent Systems "E. Caianiello" CNR, 80078 Pozzuoli, Italy
- eDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanitá, 00161 Rome, Italy
- fInstitute of Photonics, Faculty of Science, Ningbo University, 315211 Ningbo, People’s Republic of China
- gInstitute of Photonics, Faculty of Science, Ningbo University, 315211 Ningbo, People's Republic of China
- hLUMIN Laboratory (CNRS), Institut d’Alembert, Universitè Paris Saclay, 91190 Gif sur Yvette, France
- ✉Corresponding author
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Abstract
An inverted pyramidal metasurface was designed, fabricated, and studied at the nanoscale level for the development of a label-free pathogen detection on a chip platform that merges nanotechnology and surface-enhanced Raman scattering (SERS). Based on the integration and synergy of these ingredients, a virus immunoassay was proposed as a relevant proof of concept for very sensitive detection of hepatitis A virus, for the first time to our best knowledge, in a very small volume (2 μL), without complex signal amplification, allowing to detect a minimal virus concentration of 13 pg/mL. The proposed work aims to develop a high-flux and high-accuracy surface-enhanced Raman spectroscopy (SERS) nanobiosensor for the detection of pathogens to provide an effective method for early and easy water monitoring, which can be fast and convenient.