Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells
Blake Schouesta b, Brandon J. Beddingfielda, Margaret H. Gilberta, Rudolf P. Bohma, Faith R. Schiroa, Pyone P. Ayea, Antonito T. Panganibana c, Diogo M. Magnanid, Nicholas J. Manessa c e✉
- aTulane National Primate Research Center, Tulane University, Covington, LA, USA
- bBiomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA
- cDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
- dDepartment of Medicine, University of Massachusetts, Boston, MA, USA
- eDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: nmaness@tulane.edu
- ✉Corresponding author
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Abstract
Abstract While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8+ cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation, but all animals efficiently controlled the rechallenge virus, implying that the primary infection conferred adequate protection. The secondary challenge promoted humoral responses and activation of innate and adaptive immune cells, suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not solely dependent on CD8 T cells but entails multiple arms of the immune system.
TL;DRIt is confirmed that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells. (Semantic Scholar)