Adventures with Bruce Ames and the Ames test
- aDepartments of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville TN 37240-7914, United States. Electronic address: larry.marnett@vanderbilt.edu
- bDepartments of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville TN 37240-7914, United States
- ✉Corresponding author
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Abstract
Bruce Ames has had an enormous impact on human health by developing facile methods for the identification of mutagens. This research also provided important insights into the relationship between mutagenesis and carcinogenesis. Bruce is a highly innovative and creative individual who has followed his interests across disciplines into diverse fields of inquiry. The present author had the pleasure of spending a sabbatical in the Ames lab and utilized the Ames test in multiple aspects of his research. He describes both in this honorific to Bruce on the occasion of his 90th birthday.
TL;DRThis research provided important insights into the relationship between mutagenesis and carcinogenesis and utilized the Ames test in multiple aspects of his research. (Semantic Scholar)