Development of promising acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, in vitro and in silico approaches of pyridine derived fused bis-oxadiazole and bis-thiadiazole derivatives

Rafaqat Hussain^{a b}, Shoaib Khan^{c d}✉, Yousaf Khan^{d e}, Tayyiaba Iqbal^{c f}, Saeed Anwar^{a b}, Tariq A. Aziz^g✉, Metab Alharbi^h

1. ^aDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan
2. ^bDepartment of Chemistry, Hazara University, Mansehra-21120, Pakistan
3. ^cDepartment of Chemistry, AbbottabadUniversity of Science and Technology (AUST) Abbottabad, Pakistan
4. ^dDepartment of Chemistry, COMSATS University, Islamabad campus, 45550 Islamabad, Pakistan
5. ^eDepartment of Chemistry, COMSATS University Islamabad campus-45550, Islamabad, Pakistan
6. ^fDepartment of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad, Pakistan
7. ^gLaboratory of Animal Health, Food Hygiene and Quality, Department of Agriculture, University of Ioannina, 47132 Arta, Greece
8. ^hDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
9. ✉Corresponding author