Dengue virus: Etiology, epidemiology, pathobiology, and developments in diagnosis and control – A comprehensive review
Masoud Pourzangiabadia, Hamideh Najafib, Arezoo Fallahc, Aida Goudarzid, Iman Pouladie✉
- aDepartment of Microbiology, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran
- bDepartment of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address: h_najafi@ut.ac.ir
- cDepartment of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
- dDepartment of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
- e
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Abstract
Dengue flavivirus (DENV) is the virus that causes dengue, one of the most dangerous and common viral diseases in humans that are carried by mosquitoes and can lead to fatalities. Every year, there are over 400 million cases of dengue fever worldwide, and 22,000 fatalities. It has been documented in tropical and subtropical climates in over 100 nations. Unfortunately, there is no specific treatment approach, but prevention, adequate awareness, diagnosis in the early stages of viral infection and proper medical care can reduce the mortality rate. The first licensed vaccine for dengue virus (CYD Denvaxia) was quadrivalent, but it is not approved in all countries. The primary barriers to vaccine development include inadequate animal models, inadequate etiology mechanistic studies, and adverse drug events. This study provides current knowledge and a comprehensive view of the biology, production and reproduction, transmission, pathogenesis and diagnosis, epidemiology and control measures of dengue virus. • Dengue fever is a viral disease caused by Dengue virus. • Dengue virus is transmitted to humans through the bite of infected Aedes mosquitoes. These mosquitoes are often found in tropical and subtropical regions. • Currently, there is no universally licensed antiviral therapy or vaccine that protects against all four DENV serotypes. • Due to the increasing prevalence of this disease in different regions of the world, it is very important to be aware of its symptoms, ways of transmission and methods of prevention. • Globally, dengue fever is a noteworthy arboviral illness. It affects almost 50 % of the world's population and is endemic in more than 100 nations.
TL;DRThis study provides current knowledge and a comprehensive view of the biology, production and reproduction, transmission, pathogenesis and diagnosis, epidemiology and control measures of dengue virus. (Semantic Scholar)