Dengue overview: An updated systemic review
Muhammad Bilal Khana b c d, Zih‐Syuan Yanga b c d, C. C. Lina b c d, Ming-Cheng Hsua b c d, Aspiro Nayim Urbinaa c, Wanchai Assavalapsakule f, Wen‐Hung Wangg, Yen‐Hsu Chena c g h i, Sheng‐Fan Wanga b c d j k✉
- aCenter for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
- bDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
- cCenter for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan
- dDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan
- eDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
- fDepartment of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand
- gSchool of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan
- hDivision of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
- iDivision of Infectious Disease, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan
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Abstract
Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Due to a lack of antiviral drugs and effective vaccines, several therapeutic and control strategies have been proposed. A systemic literature review was conducted according to PRISMA guidelines to select proper references to give an overview of DENV infection. Results indicate that understanding the virus characteristics and epidemiology are essential to gain the basic and clinical knowledge as well as dengue disseminated pattern and status. Different factors and mechanisms are thought to be involved in the presentation of DHF and DSS, including antibody-dependent enhancement, immune dysregulation, viral virulence, host genetic susceptibility, and preexisting dengue antibodies. This study suggests that dissecting pathogenesis and risk factors as well as developing different types of therapeutic and control strategies against DENV infection are urgently needed.
TL;DRUnderstanding the virus characteristics and epidemiology are essential to gain the basic and clinical knowledge as well as dengue disseminated pattern and status and developing different types of therapeutic and control strategies against DENV infection are urgently needed. (Semantic Scholar)