Anti-diabetic effect of isoflavone rich kudzu root extract in experimentally induced diabetic rats
Kingsley C. Durua b✉, Елена Артуровна Мухлынинаc, G. A. Morozb d, Ирина Федоровна Геттеc, Irina Georgievna Danilovab c, Elena G. Kovalevab
- aDepartment of Biomedical Sciences, Macquarie University, Sydney, Australia
- bUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, Russia
- cInstitute of Immunology and Physiology of the Ural Branch of the Russia Academy of Science, Yekaterinburg, Russia
- dUral State Medical University, Yekaterinburg, Russia
- ✉Corresponding author
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Abstract
The anti-diabetic effect of isoflavone-rich kudzu extract obtained using natural deep eutectic solvent was assessed in diabetic wistar rats treated at doses of 100 mg/kg or 200 mg/kg for 28 days. Effect of treatment was based on weight, glucose tolerance, fasting glucose and glycated haemoglobin level, hepatic biochemical parameters, expression of anti-insulin and Ki67 antibodies, and histopathological evaluation of pancreas and kidney tissues. We found overall improvement in weight in diabetic rats treated with the extract at dose 200 mg/kg, but not at dose of 100 mg/kg. Plasma level of alanine transaminase (ALT) and aspartate aminotransferase (AST), but not alkaline phosphatase (ALP), were significantly different between untreated diabetic rats and those treated with the extract (p = 0.05). We found that the isoflavones-rich extract stimulated β-cell regeneration in a dose-dependent effect and showed no observable toxic impact in either the kidney or pancreas. Thus, this extract may be a promising treatment option for diabetic condition.
TL;DRIt was found that the isoflavones-rich extract stimulated β-cell regeneration in a dose-dependent effect and showed no observable toxic impact in either the kidney or pancreas, suggesting this extract may be a promising treatment option for diabetic condition. (Semantic Scholar)