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De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope
Isabelle F. T. Vianaa, Eduardo J. M. Nascimentob, Jodi K. Craigob, Marco Aurélio Kriegerc, Robbie B. Mailliardd, Rafael Dháliae, Roberto Dias Linse, Ernesto T. A. Marquesb
- aCenter for Vaccine Research and Infectious Diseases and Microbiology Department, University of Pittsburgh, Pittsburgh, PA, USA
- bMicrobiology and Molecular Genetics Department, University of Pittsburgh, Pittsburgh, PA, USA
- cCarlos Chagas Institute, FIOCRUZ, Curitiba, Brazil
- dInfectious Diseases and Microbiology Department, University of Pittsburgh, Pittsburgh, PA, USA
- eAggeu Magalhães Institute, FIOCRUZ, Recife, Brazil
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TL;DRResults show that MD simulations can help engineer vaccine antigens capable of enhancing protective antibody responses and results show that conformationally stable structures are better immunogens and can elicit the production of better antibodies. (Semantic Scholar)