Elevated Hs-CRP Levels Are Associated with Higher Risk of Intracranial Arterial Stenosis
Bing‐Jie Sua, Yi Dongb, Chen‐Chen Tana, Xiao‐He Houa, Wei Xua, Fu-Rong Suna, Mei Cuib, Qiang Dongb c✉, Lan Tana d✉, Jin‐Tai Yub e✉
- aDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China
- bDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China
- cDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China. dong_qiang@fudan.edu.cn
- dDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China. dr.tanlan@163.com
- eDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, Shanghai, 200040, China. jintai_yu@fudan.edu.cn
- ✉Corresponding author
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Abstract
Correlation between the level of high-sensitivity C-reactive protein (hs-CRP) and the incidence of intracranial arterial stenosis (ICAS) is unclear. We aim to investigate the relationship between hs-CRP levels and ICAS. A total of 1458 patients aged ≥ 40 years were enrolled in this study. All the participants had a magnetic resonance angiography (MRA) examination for the evaluation of ICAS. Participants were classified into four groups according to stroke and ICAS. Multivariable logistic regression models were used to assess the relationship of hs-CRP levels and ICAS status. A total of 432 (29.63%) subjects had ICAS. The levels of hs-CRP in stroke group were significantly higher than those in non-stroke group (p < 0.001). Patients with ICAS tend to have higher hs-CRP levels (p < 0.001). In multivariate analysis, the fourth hs-CRP quartile had the strongest association with ICAS in both stroke group and non-stroke group (OR 2.512, 95% CI 1.651-3.853, p < 0.001 for stroke group, and OR 2.534, 95% CI 1.435-4.595, p = 0.002 for non-stroke group) among the four quartiles of hs-CRP levels. Our study suggests that elevated serum hs-CRP levels are associated with higher risk of ICAS, in both stroke patients and non-stroke participants.
TL;DRIt is suggested that elevated serum hs-CRP levels are associated with higher risk of ICAS, in both stroke patients and non-stroke participants. (Semantic Scholar)