Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury—a Review
Tim W. McGlennona, J. N. Buchwaldb, Walter J. Poriesc, Fang Yud, Arthur J. Robertse, Eric P. Ahnfeldtf, Rukmini Menonc, Hēnry Buchwaldg h✉
- aStatistics Division, McGlennon MotiMetrics, Maiden Rock, WI, USA
- bDivision of Scientific Research Writing, Medwrite, Maiden Rock, WI, USA
- cBrody School of Medicine, East Carolina University, Greenville, NC, USA
- dEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA
- eLiving Heart Foundation, Little Silver, NJ, USA
- fUniformed Services University of the Health Sciences, Bethesda, MA, USA
- gSurgery and Biomedical Engineering, Owen H. & Sarah Davidson Wangensteen Chair in Experimental Surgery, Emeritus, University of Minnesota Medical School, 420 Delaware Street SE, MMC 195, Minneapolis, MN, 55455, USA. buchw001@umn.edu
- hSurgery and Biomedical Engineering, Owen H. & Sarah Davidson Wangensteen Chair in Experimental Surgery, Emeritus, University of Minnesota Medical School, 420 Delaware Street SE, MMC 195, Minneapolis, MN, 55455, USA
- ✉Corresponding author
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Abstract
Obesity is a common outcome of traumatic brain injury (TBI) that exacerbates principal TBI symptom domains identified as common areas of post-TBI long-term dysfunction. Obesity is also associated with increased risk of later-life dementia and Alzheimer's disease. Patients with obesity and chronic TBI may be more vulnerable to long-term mental abnormalities. This review explores the question of whether weight loss induced by bariatric surgery could delay or perhaps even reverse the progression of mental deterioration. Bariatric surgery, with its induction of weight loss, remission of type 2 diabetes, and other expressions of the metabolic syndrome, improves metabolic efficiency, leads to reversal of brain lesions seen on imaging studies, and improves function. These observations suggest that metabolic/bariatric surgery may be a most effective therapy for TBI.
TL;DRobesity is a common outcome of traumatic brain injury that exacerbates principal TBI symptom domains identified as common areas of post-TBI long-term dysfunction, and bariatric surgery, with its induction of weight loss, remission of type 2 diabetes, and other expressions of the metabolic syndrome, improves metabolic efficiency and leads to reversal of brain lesions seen on imaging studies. (Semantic Scholar)