Generation of diverse cortical inhibitory interneurons
Khadeejah T. Sultana b c d, Song‐Hai Shia b c d✉
- aDevelopmental Biology Program Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center New York NY USA
- bNeuroscience Graduate Program Weill Cornell Medical College New York NY USA
- cDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- dNeuroscience Graduate Program, Weill Cornell Medical College, New York, NY, USA
- ✉Corresponding author
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Abstract
First described by Ramon y Cajal as 'short-axon' cells over a century ago, inhibitory interneurons in the cerebral cortex make up ~20-30% of the neuronal milieu. A key feature of these interneurons is the striking structural and functional diversity, which allows them to modulate neural activity in diverse ways and ultimately endow neural circuits with remarkable computational power. Here, we review our current understanding of the generation of cortical interneurons, with a focus on recent efforts to bridge the gap between progenitor behavior and interneuron production, and how these aspects influence interneuron diversity and organization. WIREs Dev Biol 2018, 7:e306. doi: 10.1002/wdev.306 This article is categorized under: Nervous System Development > Vertebrates: General Principles.
TL;DRCurrent understanding of the generation of cortical interneurons is reviewed, with a focus on recent efforts to bridge the gap between progenitor behavior and interneuron production, and how these aspects influence internuron diversity and organization. (Semantic Scholar)