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N. Gray · SciRah

Researcher profile · Semantic Scholar

N. Gray

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N. Gray — researcher profile on SciRah

h-index: 137
Works: 685
Citations: 76K

Most-cited papers

Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway
K. Kurppa, Yao Liu, Ciric To, Ting-Hu Zhang +40 more
2020Cancer Cell432 citations Open access
Semantic Scholar
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Behnam Nabet, F. Ferguson, B. Seong, Miljan Kuljanin +9 more
2020Nature Communications256 citations Open access
Semantic Scholar
An embryonic diapause-like adaptation with suppressed Myc activity enables tumor treatment persistence
Eugen Dhimolea, R. de Matos Simoes, Dhvanir N. Kansara, Aziz M. Al'Khafaji +27 more
2021Cancer Cell245 citations Open access
Semantic Scholar
Targeting Pin1 Renders Pancreatic Cancer Eradicable by Synergizing with Immunochemotherapy
Kazuhiro Koikawa, S. Kibe, Futoshi Suizu, Nobufumi Sekino +22 more
2021Cell195 citations Open access
Semantic Scholar
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
S. Vervoort, S. A. Welsh, J. Devlin, E. Barbieri +29 more
2021Cell181 citations Open access
Semantic Scholar
Rewiring cancer drivers to activate apoptosis
S. Gourisankar, A. Krokhotin, Wen-heng Ji, Xiao-Fan Liu +11 more
2022bioRxiv137 citations Open access
Semantic Scholar
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors
Qing Li, Bai-Shan Jiang, Jiaye Guo, H. Shao +21 more
2021Cancer Discovery137 citations Open access
Semantic Scholar
Targeting transcription cycles in cancer
S. Vervoort, J. Devlin, Nicholas Kwiatkowski, Ming-Xing Teng +2 more
2021Nature Reviews. Cancer137 citations
Semantic Scholar
Allosteric inhibition of drug resistant forms of EGFR L858R mutant NSCLC
Ciric To, T. Beyett, Jaebong Jang, W. Feng +22 more
2022Nature Cancer124 citations Open access
Semantic Scholar
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
C. Dubiella, Benika J. Pinch, Kazuhiro Koikawa, D. Zaidman +40 more
2021Nature Chemical Biology120 citations Open access
Semantic Scholar
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer
Jie-Hui Deng, A. Thennavan, Igor Dolgalev, Ting Chen +34 more
2021Nature Cancer119 citations Open access
Semantic Scholar
Discovery and Resistance Mechanism of a Selective CDK12 Degrader
Bai-Shan Jiang, Yang Gao, Jian-Wei Che, Wenchao Lu +13 more
2021Nature Chemical Biology116 citations Open access
Semantic Scholar
Inhibition of CDK4/6 promotes CD8 T cell memory formation
Max Heckler, Lestat R. Ali, E. Clancy-Thompson, Li Qiang +20 more
2021Cancer Discovery109 citations Open access
Semantic Scholar
Acute pharmacological degradation of Helios destabilizes regulatory T cells
Eric S. Wang, Alyssa L Verano, R. Nowak, J. Yuan +8 more
2021Nature Chemical Biology102 citations Open access
Semantic Scholar
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
B. Seong, N. Dharia, Shan Lin, K. Donovan +17 more
2021Cancer Cell98 citations Open access
Semantic Scholar
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Ryosuke Shirasaki, G. Matthews, Sara Gandolfi, R. de Matos Simoes +35 more
2021Cell Reports92 citations Open access
Semantic Scholar
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
T. Beyett, Ciric To, D. Heppner, Jaimin K. Rana +8 more
2022Nature Communications84 citations Open access
Semantic Scholar
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
Zebulon G. Levine, S. C. Potter, C. Joiner, George Q. Fei +6 more
2020Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Fragment-based covalent ligand discovery
Wenchao Lu, M. Kostic, Ting-Hu Zhang, Jian-Wei Che +4 more
2021RSC Chemical Biology77 citations Open access
Semantic Scholar
Exploring the Target Scope of KEAP1 E3 Ligase-based PROTACs
Guang-Yan Du, Jie Jiang, Nathaniel J. Henning, N. Safaee +15 more
2022Cell Chemical Biology76 citations Open access
Semantic Scholar
Prospects for Antibacterial Discovery & Development
T. M. Privalsky, Alexander M. Soohoo, Jin-Hua Wang, C. Walsh +4 more
2021Journal of the American Chemical Society71 citations Open access
Semantic Scholar
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2
Ken Morita, Shu-Ning He, R. Nowak, Jin-Hua Wang +8 more
2020Cell71 citations Open access
Semantic Scholar
Identification of a potent and selective covalent Pin1 inhibitor
Benika J. Pinch, Zainab M. Doctor, Behnam Nabet, Christopher M. Browne +21 more
2020Nature Chemical Biology70 citations Open access
Semantic Scholar
Development of PDE6D and CK1α Degraders Through Chemical Derivatization of FPFT-2216
Ming-Xing Teng, Wenchao Lu, K. Donovan, Jialin Sun +8 more
2021Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Bai-Shan Jiang, Jie Jiang, I. Kaltheuner, A. Iniguez +12 more
2021European journal of medicinal chemistry53 citations Open access
Semantic Scholar
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2
Guang-Yan Du, Jie Jiang, Qi-Biao Wu, Nathaniel J. Henning +8 more
2021Angewandte Chemie52 citations Open access
Semantic Scholar
Targeting the PI5P4K lipid kinase family in cancer using covalent inhibitors
S. Sivakumaren, Hyeseok Shim, Ting-Hu Zhang, F. Ferguson +17 more
2020Cell Chemical Biology46 citations Open access
Semantic Scholar
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
Diana Y. Lu, J. Ellegast, K. Ross, Clare F. Malone +15 more
2023Nature Cell Biology43 citations Open access
Semantic Scholar
Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy
M. Silva, Ghata Nandi, K. Donovan, Q. Cai +6 more
2022Frontiers in Cellular Neuroscience43 citations Open access
Semantic Scholar
Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation
I. Kaltheuner, K. Anand, Jonas Moecking, Robert Düster +3 more
2021Nature Communications43 citations Open access
Semantic Scholar
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
Mengyang Fan, Wenchao Lu, Jian-Wei Che, Nicholas Kwiatkowski +22 more
2022bioRxiv42 citations Open access
Semantic Scholar
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Austin Hsu, Qiming Duan, Sarah McMahon, Yu Huang +5 more
2020Journal of Clinical Investigation41 citations Open access
Semantic Scholar
CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma
Yao Yao, Jessica Fong Ng, W. D. Park, M. Samur +16 more
2023Blood35 citations Open access
Semantic Scholar
Genome-Scale Functional Genomics Identify Genes Preferentially Essential for Multiple Myeloma Cells compared to other Neoplasias
R. de Matos Simoes, Ryosuke Shirasaki, Sondra Downey-Kopyscinski, G. Matthews +37 more
2023Nature Cancer35 citations
Semantic Scholar
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
Hadley E. Sheppard, Alessandra Dall’Agnese, W. D. Park, M. Shamim +15 more
2021Cell Reports Medicine34 citations Open access
Semantic Scholar
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
S. Mehta, Altantsetseg Buyanbat, Yan Kai, Özge Karayel +13 more
2022Cell Chemical Biology33 citations Open access
Semantic Scholar
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Yen-Der Li, Michelle W. Ma, Muhammad Murtaza Hassan, M. Hunkeler +24 more
2023bioRxiv31 citations Open access
Semantic Scholar
Inhibition of the deubiquitinase USP10 induces degradation of SYK
Jing Yang, Chengcheng Meng, E. Weisberg, Abigail E. Case +10 more
2020British Journal of Cancer30 citations Open access
Semantic Scholar
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
Jieun Son, Jaebong Jang, T. Beyett, Yoonji Eum +14 more
2022Cancer Research29 citations Open access
Semantic Scholar
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P‑Loop Cysteine
Guang-Yan Du, S. Rao, D. Gurbani, Nathaniel J. Henning +10 more
2020Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Anna Carli, Shoukat Afshar-Sterle, A. Rai, Hao-Yun Fang +7 more
2021Proteomics27 citations Open access
Semantic Scholar
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors
He-Min Zhu, Scott B. Ficarro, William M. Alexander, Laura E. Fleming +11 more
2021Analytical Chemistry27 citations Open access
Semantic Scholar
The HCK/BTK inhibitor KIN-8194 is active in MYD88 driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance.
Guang Yang, Jin-Hua Wang, L. Tan, M. Munshi +18 more
2021Blood27 citations Open access
Semantic Scholar
Development and utility of a PAK1-selective degrader
Hoi-Yee Chow, Sofiia Karchugina, Brian J. Groendyke, S. Toenjes +8 more
2022bioRxiv25 citations Open access
Semantic Scholar
Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts
J. Ellegast, G. Alexe, A. Hamze, Shan Lin +12 more
2021Blood25 citations Open access
Semantic Scholar
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1
Wenchao Lu, Yao Liu, Yang Gao, Qi-Xiang Geng +18 more
2023Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC
Thomas W. Gero, D. Heppner, T. Beyett, Ciric To +12 more
2022Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Catalytic domain plasticity of MKK7 reveals structural mechanisms of allosteric activation and new targeting opportunities
Martin Schröder, L. Tan, Jin-Hua Wang, Yanke Liang +3 more
2020bioRxiv24 citations Open access
Semantic Scholar
Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma
Yang Gao, Marina P Volegova, Nicole Nasholm, Sanjukta Das +7 more
2022Frontiers in Oncology23 citations Open access
Semantic Scholar
The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug.
Ming-Xing Teng, Marlise R. Luskin, S. Cowan-Jacob, Qiang Ding +2 more
2022Journal of Medicinal Chemistry23 citations
Semantic Scholar

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