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E. Lein · SciRah

Researcher profile · Semantic Scholar

E. Lein

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E. Lein — researcher profile on SciRah

h-index: 64
Works: 196
Citations: 42K

Most-cited papers

A multimodal cell census and atlas of the mammalian primary motor cortex
E. Callaway, Hong-wei Dong, J. Ecker, Mike Hawrylycz +254 more
2020Nature465 citations Open access
Semantic Scholar
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells
N. Gouwens, S. Sorensen, Fahimeh Baftizadeh, Agata Budzillo +94 more
2020Cell457 citations Open access
Semantic Scholar
Integrated multimodal cell atlas of Alzheimer’s disease
M. Gabitto, K. Travaglini, V. Rachleff, E. Kaplan +104 more
2024bioRxiv327 citations Open access
Semantic Scholar
Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex
Luke Campagnola, Stephanie C. Seeman, Thomas Chartrand, Lisa Kim +85 more
2021bioRxiv318 citations Open access
Semantic Scholar
Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue
Daniel Gyllborg, C. Langseth, Xiaoyan Qian, Eunkyoung Choi +4 more
2020Nucleic Acids Research257 citations Open access
Semantic Scholar
Enhancer viruses for combinatorial cell subclass-specific labeling
Lucas T. Graybuck, T. Daigle, Adriana E. Sedeño-Cortés, Miranda P. Walker +33 more
2021Neuron151 citations Open access
Semantic Scholar
Single Cell DNA Methylation and 3D Genome Architecture in the Human Brain
Wei Tian, Jing-Tian Zhou, Anna Bartlett, Qiurui Zeng +35 more
2023Science129 citations Open access
Semantic Scholar
Cell type ontologies of the Human Cell Atlas
David Osumi-Sutherland, Chuan Xu, M. Keays, A. P. Levine +4 more
2021Nature Cell Biology114 citations Open access
Semantic Scholar
Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons
B. Kalmbach, R. Hodge, Nikolas L. Jorstad, Scott F. Owen +27 more
2021Neuron100 citations Open access
Semantic Scholar
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
J. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney +35 more
2019bioRxiv100 citations Open access
Semantic Scholar
Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Thomas Chartrand, R. Dalley, J. Close, N. Goriounova +86 more
2022bioRxiv88 citations Open access
Semantic Scholar
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
J. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney +38 more
2021Cell Reports81 citations Open access
Semantic Scholar
A machine learning method for the discovery of minimum marker gene combinations for cell type identification from single-cell RNA sequencing
B. Aevermann, Yun Zhang, M. Novotny, Mohamed Keshk +6 more
2021Genome Research67 citations Open access
Semantic Scholar
Single-cell genomics and regulatory networks for 388 human brains
Prashant S. Emani, Jason J. Liu, Declan Clarke, Matthew Jensen +76 more
2024bioRxiv61 citations Open access
Semantic Scholar
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex
S. Hunt, Yoni Leibner, E. Mertens, Natalí Barros-Zulaica +23 more
2022Cerebral Cortex58 citations Open access
Semantic Scholar
Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans
Trygve E Bakken, C. V. van Velthoven, V. Menon, R. Hodge +25 more
2021eLife58 citations Open access
Semantic Scholar
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
I. Liu, Gustavo Alencastro Veiga Cruzeiro, Lynn Bjerke, Rebecca F. Rogers +67 more
2024Cancer Cell57 citations Open access
Semantic Scholar
Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization
Brian R. Lee, Agata Budzillo, Kristen Hadley, Jeremy A. Miller +24 more
2021eLife53 citations Open access
Semantic Scholar
A guide to the BRAIN Initiative Cell Census Network data ecosystem
M. Hawrylycz, Maryann E. Martone, G. Ascoli, J. Bjaalie +99 more
2023PLoS Biology52 citations Open access
Semantic Scholar
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage
K. Börner, P. Blood, Jonathan C. Silverstein, Matthew Ruffalo +165 more
2025Nature Methods50 citations Open access
Semantic Scholar
Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
H. Suresh, M. Crow, Nikolas L. Jorstad, R. Hodge +4 more
2023Nature Ecology & Evolution50 citations Open access
Semantic Scholar
Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types
Anirban Nandi, Thomas Chartrand, Werner Van Geit, A. Buchin +11 more
2020bioRxiv50 citations Open access
Semantic Scholar
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample
N. Postupna, Shannon E. Rose, L. Gibbons, Natalie M Coleman +18 more
2021Frontiers in Neurology48 citations Open access
Semantic Scholar
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Xinhong Chen, Damien A Wolfe, D. S. Bindu, Mengying Zhang +26 more
2023bioRxiv41 citations Open access
Semantic Scholar
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
Yoav Ben-Simon, Marcus Hooper, S. Narayan, T. Daigle +145 more
2025Cell38 citations Open access
Semantic Scholar
Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons
N. Gouwens, S. Sorensen, Fahimeh Baftizadeh, Agata Budzillo +93 more
2020bioRxiv34 citations Open access
Semantic Scholar
An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease
A. Arnsten, K. Del Tredici, N. Barthélemy, M. Gabitto +4 more
2025Alzheimer's & Dementia33 citations Open access
Semantic Scholar
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits
Avery C. Hunker, Morgan E. Wirthlin, Gursajan Gill, Nelson J. Johansen +132 more
2024bioRxiv33 citations Open access
Semantic Scholar
Parallel RNA and DNA analysis after deep sequencing (PRDD-seq) reveals cell type-specific lineage patterns in human brain
A. Huang, Pengpeng Li, Rachel E. Rodin, S. Kim +10 more
2020Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Cellular resolution anatomical and molecular atlases for prenatal human brains
Song-Lin Ding, J. Royall, Phil Lesnar, Benjamin A. C. Facer +27 more
2021bioRxiv32 citations Open access
Semantic Scholar
A scalable and modular automated pipeline for stitching of large electron microscopy datasets
G. Mahalingam, R. Torres, D. Kapner, Eric T. Trautman +18 more
2021bioRxiv29 citations Open access
Semantic Scholar
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Y. Zeighami, Trygve E Bakken, T. Nickl-Jockschat, Zeru J. Peterson +6 more
2023PLoS Biology28 citations Open access
Semantic Scholar
Multi-modal characterization and simulation of human epileptic circuitry
A. Buchin, Rebecca de Frates, Anirban Nandi, Rusty Mann +15 more
2020bioRxiv28 citations Open access
Semantic Scholar
Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types
Anirban Nandi, Thomas Chartrand, Werner Van Geit, A. Buchin +11 more
2022Cell Reports22 citations Open access
Semantic Scholar
Morpho-electric diversity of human hippocampal CA1 pyramidal neurons
E. Mertens, Yoni Leibner, Jean Pie, A. Galakhova +17 more
2024Cell Reports19 citations Open access
Semantic Scholar
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Monet +33 more
2023eLife19 citations Open access
Semantic Scholar
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Machen +33 more
2020bioRxiv19 citations Open access
Semantic Scholar
The commitment of the human cell atlas to humanity
I. Amit, K. Ardlie, Fabiana Arzuaga, G. Awandare +38 more
2024Nature Communications18 citations Open access
Semantic Scholar
FR-Match: robust matching of cell type clusters from single cell RNA sequencing data using the Friedman–Rafsky non-parametric test
Yun Zhang, B. Aevermann, Trygve E Bakken, Jeremy A. Miller +3 more
2020bioRxiv18 citations Open access
Semantic Scholar
Reference-based cell type matching of in situ image-based spatial transcriptomics data on primary visual cortex of mouse brain
Yun Zhang, Jeremy A. Miller, Jeongbin Park, B. Lelieveldt +14 more
2023Scientific Reports17 citations Open access
Semantic Scholar
Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia
A. Huang, Zi-Nan Zhou, Maya Talukdar, Michael B. Miller +19 more
2024bioRxiv14 citations Open access
Semantic Scholar
Parallel RNA and DNA analysis after Deep-sequencing (PRDD-seq) reveals cell type specific lineage patterns in human brain
A. Huang, Pengpeng Li, Rachel E. Rodin, S. Kim +10 more
2020bioRxiv14 citations Open access
Semantic Scholar
Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex
Brian R. Lee, R. Dalley, Jeremy A. Miller, Thomas Chartrand +90 more
2022bioRxiv13 citations Open access
Semantic Scholar
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
M. Murray, Colin M. Smith, Vilas Menon, C. Keene +42 more
2025Neuron12 citations Open access
Semantic Scholar
Mapping Human Tissues with Highly Multiplexed RNA in situ Hybridization
K. Kalhor, Chienju Chen, Ho-Suk Lee, Matthew Cai +16 more
2023bioRxiv12 citations Open access
Semantic Scholar
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
A. Huang, Zi-Nan Zhou, Maya Talukdar, L. Enyenihi +31 more
2026Cell11 citations Open access
Semantic Scholar
Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons
N. Dembrow, Scott Sawchuk, R. Dalley, Ximena Opitz-Araya +24 more
2024Cell Reports11 citations Open access
Semantic Scholar
Hybridization-based In Situ Sequencing (HybISS): spatial transcriptomic detection in human and mouse brain tissue
Daniel Gyllborg, C. Langseth, Xiaoyan Qian, Sergio Marco Salas +3 more
2020bioRxiv11 citations Open access
Semantic Scholar
AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders
Meagan A. Quinlan, Rong Guo, Andrew G. Clark, Em Luber +19 more
2025Molecular Therapy10 citations Open access
Semantic Scholar
Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structures
Wei-ping Tian, Jing-Tian Zhou, Anna Bartlett, Qiurui Zeng +34 more
2022bioRxiv10 citations Open access
Semantic Scholar

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